Journal of Asthma, Allergy and Clinical Immunology  2001;21(2):250-254

A case of cold urticaria showing metachromasia in skin biopsy.

Soo In CHOI 1 ; An Soo JANG ; Jae Hong PARK ; Hoon YOO ; Yoon Kyung KIM ; Young Cheol KIM ; Jeong Seog KIM ; Seong Hee OH ; Jee Shin LEE

Affiliations

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Keywords

cold urticaria; ice cube test; metachromatic cell

Country

Republic of Korea

Language

Korean

Abstract

The patient was a 24-year-old male who complained of urticaria upon exposure to cold air and after showering in cold water. Allergic skin tests were positive for cockroach. To determine whether he had cold urticaria, we performed an ice cube test. The patient complained of pruritus, erythema, and wheals appeared at 10min. Skin biopsy specimens collected 10 minutes after ice-cube test showed perivascular mononuclear cell infiltration and edema in hematoxylin and eosin stains, and metachromatic cell and degranulation in toluidine blue stain.