Kosin Medical Journal  2014;29(1):63-68

doi:10.7180/kmj.2014.29.1.63

A Case of Seizure and Metabolic Acidosis Due to Renal Adjustment Dosage of Isoniazid in an Elderly Woman.

Young Shin SHIN 1 ; Eun Hee SIM ; Chang Woo YEO ; Jin Doo KANG ; Ji Yeon KIM ; Seon Ja PARK

Affiliations

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Keywords

Isoniazid; Metabolic acidosis; Pyridoxine; Seizure

Country

Republic of Korea

Language

Korean

Abstract

Isoniazid is one of the most commonly used antituberculosis drug. Acute into xication is characterized by repetitious convulsions, high anion gap metabolic a cidosis and coma. The basis of theraphy consists of parental pyridoxine admi nistration in a dose equivalent to that of isoniazid ingested. Here we present a case of seizure and metabolic acidosis due to only renal adjustment dosage of Isoniazid in an elderly woman.