Chinese Journal of Plastic Surgery 2016;32(1):52-55

Whole-genome sequencing on one case of Han familial keloids.

Guodong TENG ; Minliang CHEN ; Chang LIU ; Liming LIANG

Country

China

Language

Chinese

Abstract

OBJECTIVETo screen SNP information of keloid pedigrees through whole genome sequencing.

METHODSWe Collected information and clinical data of the keloid pedigree and constructed charts of the pedigree. The DNA was extracted from peripheral venous blood samples of the pedigree to sequence the whole genome.

RESULTS27 SNP and 8 disease-associated genes were screened out.

CONCLUSIONSWhole genome sequencing technology can select new genetic mutations associated with keloid, and provide a new way for the research of keloid.