Clinical and Experimental Reproductive Medicine  2013;40(4):143-147

doi:10.5653/cerm.2013.40.4.143

In vitro maturation: Clinical applications.

Kyung Sil LIM 1 ; Soo Jin CHAE ; Chang Woo CHOO ; Yeon Hee KU ; Hye Jun LEE ; Chang Young HUR ; Jin Ho LIM ; Won Don LEE

Affiliations

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Keywords

In vitro maturation; Ovarian hyperstimulation syndrome; Infertility

Country

Republic of Korea

Language

English

Abstract

Oocyte in vitro maturation (IVM) is an assisted reproductive technology in which oocytes are retrieved from the antral follicles of unstimulated or minimally stimulated ovaries. IVM of human oocytes has emerged as a promising procedure. This new technology has advantages over controlled ovarian stimulation such as reduction of costs, simplicity, and elimination of ovarian hyperstimulation syndrome. By elimination or reduction of gonadotropin stimulation, IVM offers eligible infertile couples a safe and convenient form of treatment, and IVM outcomes are currently comparable in safety and efficacy to those of conventional in vitro fertilization. IVM has been applied mainly in patients with polycystic ovary syndrome or ultrasound-only polycystic ovaries, but with time, the indications for IVM have expanded to other uncommon situations such as fertility preservation, as well as to normal responders. In this review, the current clinical experiences with IVM will be described.