Asian Pacific Journal of Tropical Biomedicine  2014;4(8):663-668

doi:10.12980/APJTB.4.2014APJTB-2014-0155

Iron-chelating and anti-lipid peroxidation properties of 1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one (CM1) in long-term iron loading β-thalassemic mice.

Kanokwan KULPRACHAKARN 1 ; Nittaya CHANSIW 1 ; Kanjana PANGJIT 2 ; Chada PHISALAPHONG 3 ; Suthat FUCHAROEN 4 ; Robert C HIDER 5 ; Sineenart SANTITHERAKUL 6 ; Somdet SRICHAIRATANAKOOL 1

Affiliations

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Keywords

Iron chelator; Iron overload; Iron-chelating; Lipid peroxidation; Non-transferrin bound iron; β-thalassemia

Country

China

Language

English

Abstract

OBJECTIVETo evaluate the iron-chelating properties and free-radical scavenging activities of 1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one (CM1) treatment in chronic iron-loaded β-thalassemic (BKO) mice.

METHODSThe BKO mice were fed with a ferrocene-rich diet and were orally administered with CM1 [50 mg/(kg.day)] for 6 months. Blood levels of non-transferrin bound iron, labile plasma iron, ferritin (Ft) and malondialdehyde were determined.

RESULTSThe BKO mice were fed with an iron diet for 8 months which resulted in iron overload. Interestingly, the mice showed a decrease in the non-transferrin bound iron, labile plasma iron and malondialdehyde levels, but not the Ft levels after continuous CM1 treatment.

CONCLUSIONSCM1 could be an effective oral iron chelator that can reduce iron overload and lipid peroxidation in chronic iron overload β-thalassemic mice.