Chinese Journal of Virology 2013;29(4):465-470

Research advances in the Cap gene of circovirus and its encoding capsid protein.

Yu XU 1 ; Ren-Yong JIA

Affiliations

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Country

China

Language

Chinese

Abstract

The Cap gene of antisense strand of circovirus has the most variation of the genome, and encodes a capsid protein which has the main immunogenicity. The N-terminal of capsid protein makes up of nuclear localization signal which is involved with virus location. This review summarizes the research advance of Cap gene of circovirus in the sequence characteristics, its encoding capsid protein, basic functions of the capsid protein and its interaction with MKRN1 protein, Hsp40 protein, receptor protein gClqR and complement factor C1qB protein. This paper lays a theory foundation for the further study of the capsid protein in the aspects of viral attachment, replication and transportation.