Laboratory Medicine Online  2012;2(2):101-104

doi:10.3343/lmo.2012.2.2.101

A Case of Acute Myeloid Leukemia Transformed from JAK2 V617F-Positive Chronic Neutrophilic Leukemia.

Jae Hee LEE 1 ; Jung Sook HA ; Nam Hee RYOO ; Dong Seok JEON ; Jae Ryong KIM

Affiliations

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Keywords

AML; Chronic neutrophilic leukemia; JAK2 V617F; Myeloproliferative neoplasm

Country

Republic of Korea

Language

Korean

Abstract

Chronic neutrophilic leukemia (CNL) is a rare myeloproliferative neoplasm (MPN) characterized by persistent peripheral blood neutorphilia, bone marrow hypercellularity of neutrophilic granulocyte proliferation and hepatosplenomegaly. Acquired somatic mutation, JAK2 V617F, is the only molecular marker known to have association with classic BCR-ABL1 negative MPNs. However, JAK2 V617F has been detected occasionally in other MPNs such as CNL or other disease entities. We experienced a case of CNL with JAK2 V617F mutation. The patient was diagnosed according to the 2008 WHO classification criteria, and developed AML 9 months after the diagnosis of CNL. The JAK2 V617F was detected in the bone marrow throughout the clinical course. More cases are needed to establish the role of JAK2 V617F in the pathogenesis, prognosis and disease course of CNL.