Acta Physiologica Sinica 2013;65(1):89-95

Effects of SUMOylation on the subcellular localization and function of DAXX.

Ling LI 1 ; Juan WEN ; Qin-Hui TUO ; Duan-Fang LIAO

Affiliations

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Country

China

Language

Chinese

Abstract

Death domain-associated protein (DAXX) as a multifunctional nuclear protein widely resides in nucleolus, nucleoplasm, chromatin, promyelocytic leukaemia nuclear bodies (PML-NBs) and cytoplasm. It plays significant roles in transcriptional regulation, apoptosis, cell cycle and other biological activities. Small ubiquitin-like modifier (SUMO) is required for SUMOylation which is a highly conserved post-translational modification in a wide variety of cellular processes. Numerous studies demonstrated that SUMOylation has a great effect on the subcellular localization and functional regulation of DAXX. This review will provide a summary for SUMOylation of DAXX.