Korean Journal of Critical Care Medicine  2015;30(3):207-211

doi:10.4266/kjccm.2015.30.3.207

Acute Colchicine Poisoning Treated with Granulocyte Colony Stimulating Factor and Transfusion.

Sung Hwa LEE ; Sung Wook PARK ; Sang Kyoon HAN ; Soon Chang PARK

Keywords

colchicine; neutropenia; toxicity

Country

Republic of Korea

Language

English

Abstract

Colchicine poisoning is rare but can cause potentially life-threatening toxic complications such as hypovolemic shock, cardiovascular collapse and multiple organ failure. In this case report, we describe a case of a 20-year-old female who presented to the emergency department after suicidal ingestion of a toxic dose of colchicine. She developed thrombocytopenia, neutropenia and acute respiratory distress syndrome that required blood transfusion and administration of granulocyte colony stimulating factor for the prevention of infectious complications. With regard to the clinical manifestations of colchicine toxicity, we discussed suggested mechanisms.