Journal of Zhejiang University. Medical sciences 2011;40(2):222-229

Toll-like receptors and their role in pathogenesis and vaccine study of cutaneous diseases.

Wei-Wei ZHANG 1 ; Xiao-Hong MAO

Affiliations

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Country

China

Language

Chinese

Abstract

Toll like receptor (TLR) can specifically recgnize pathogen-associated molecular patterns (PAMPs) and is considered as an important link between innate and adaptive immunity. It has been shown that TLR plays an important role in the pathogenesis and pathophysiology of a variety of skin diseases. Moreover, TLR agonists have exhibited promising therapeutic effects on the disease models and are expected to be novel vaccine adjuvants. Investigations of the underlying mechanism will give new insights into these diseases. This review will discuss the relationship between TLR and pathogenesis and management of some cutaneous diseases.