Journal of Zhejiang University. Medical sciences 2011;40(3):252-258

Association of XPC gene polymorphisms with breast cancer risk.

Yin-yin WU 1 ; Xin-yuan MA ; Kai-yan YAO ; Qi-long LI ; Kun CHEN

Affiliations

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Country

China

Language

Chinese

Abstract

OBJECTIVETo access the association of xeroderma pigmentosum group C (XPC) Lys939Gln (A/C) and Ala499Val (C/T) polymorphisms with breast cancer risk in a Chinese Han population.

METHODS173 patients with breast cancer and 171 matched controls in terms of habitation and age (±5 years) were included in this population-based case-control study. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was employed to genotyping the Lys939Gln and Ala499Val polymorphisms. Associations of genotypes of Lys939Gln and Ala499Val with breast cancer risk were evaluated using unconditional logistic regression model. Associations between XPC haplotypes and breast cancer risk were estimated by Haplo. Stats package.

RESULTNo significant associations were observed both in individual SNPs and haplotype analyses. However, there was a significant interaction between XPC Lys939Gln polymorphism and menopausal status (P=0.032).

CONCLUSIONThe XPC Lys939Gln polymorphism may modulate breast cancer susceptibility jointly with the menopausal status.