Chinese Journal of Applied Physiology 2008;24(3):286-289

Arrhythmia triggered by stretching rabbit left ventricles and the block effect of streptomysin.

Hua WEI 1 ; Zhi-Fei ZHANG ; Hai-Xia HUANG ; Wei-Zhen NIU

Affiliations

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Country

China

Language

Chinese

Abstract

AIMTo observe the effect of stretching left ventricles in the end of action potential on rabbit cardiac activity, and to investigate its possible mechanisms.

METHODSStretch (120 mmHg, 50 ms) was applied in the end of action potential by the pressure-clamp technique to observe if there would be any changes in rabbit cardiac activity and streptomycin (500 micromol/L) was used to identify the mechanism.

RESULTSStretch in the end of action potential caused arrhythmia (P < 0.05) and streptomycin blocked the above effect (P < 0.05).

CONCLUSIONStreptomycin could block the effect of stretching left ventricles in the end of action potential on rabbit cardiac activity, which indicates that stretch-activated ion channels involve it.