West China Journal of Stomatology 2017;35(1):99-103

doi:10.7518/hxkq.2017.01.016

Research progression of the relationship between integrin α2β1 and drug-induced gingival overgrowth.

Yingzhu KANG 1 ; Shujuan GUO 2

Affiliations

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Keywords

collagen phagocytosis; collagens metabolism; drug-induced gingival overgrowth; integrin α2β1

Country

China

Language

Chinese

Abstract

Drug-induced gingival overgrowth (DIGO) is characterized by fibrous gingival hyperplasia and increased gingival volume. DIGO is histologically associated with proliferation of cells and deposition of extracellular matrices, particularly collagen. Integrin α2β1 is related to collagen phagocytosis and involved in the occurrence and progression of DIGO. This paper reviews the progress of research on the relationship between integrin α2β1 and DIGO.