Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2005;40(12):899-902

Expression and significance of interleukin-17 and its receptor in nasal polyps.

Xin WANG 1 ; Zhen DONG

Affiliations

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Country

China

Language

Chinese

Abstract

OBJECTIVETo detect the expression and distribution of interleukin-17 and interleukin 17 receptor (IL-17R) in nasal polyps and to probe into their significance in the pathology of nasal polyps.

METHODSThe methods of immunohistochemical staining and western blot were used to detect IL-17 and IL-17R in nasal polyps and controls.

RESULTSIn nasal polyp tissues, IL-17 expressed mainly in cytoplasm of plasm cell, less in prickle-cell layer of the epithelium and the acinus of the serous gland. In turbinates, IL-17 also expressed in the cytoplasm of the plasm cell, the prickle-cell layer of the epithelium and the acinus of the serous gland. The expression of IL-17 between nasal polyps and turbinates differed significantly (t = 2.237, 2.176, 2.246, P < 0.05, respectively). Both IL-17 and IL-17R displayed specific bands in nasal polyps and turbinates, but the bands of IL-17 and IL-17R in nasal polyps were stronger than those in turbinates.

CONCLUSIONSIL-17 may have an important role in the occurrence of nasal polyps by specific combination with IL-17R and over-expression in nasal polyps.