Journal of Integrative Medicine 2014;12(6):469-475

doi:10.1016/S2095-4964(14)60053-4

Role of adult resident renal progenitor cells in tubular repair after acute kidney injury.

Hui-ling WANG 1 2 ; E-mail: VIOLLLA@163.COM. ; Nan-mei LIU 3 ; Rui LI 3 ;

Affiliations

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Country

China

Language

English

Abstract

Acute kidney injury is a serious global health problem and determinant of morbidity and mortality. Recent advancements in the field of stem cell research raise hopes for stem cell-based regenerative approaches to treat acute kidney diseases. In this review, the authors summarized the latest research advances of the adult resident renal progenitor cells (ARPCs) on kidney repair, the role of ARPCs on tubular regeneration after acute kidney injury, the current understanding of the mechanisms related to ARPC activation and modulation, as well as the challenges that remain to be faced.