Journal of Southern Medical University 2011;31(3):564-566

Effect of short-term intensive therapy with glimepiride and metformin in newly diagnosed type 2 diabetic patients.

Min WANG 1 ; Fang GAO ; Yao-ming XUE ; Ya-juan HAN ; Xia-jun FU ; Fei-ying HE

Affiliations

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Country

China

Language

Chinese

Abstract

OBJECTIVETo evaluate the effect of short-term intensive therapy on blood glucose control, BETA-cell function, and blood lipid levels in newly diagnosed type 2 diabetic patients.

METHODSOut-patients with newly diagnosed type 2 diabetic patients were enrolled for intensive treatment with sulfonylureas and metformin for 12 weeks, and the therapeutic effect was evaluated.

RESULTSAfter the intensive treatment, FPG, 2 hPG, and HbA1c decreased significantly (P<0.01); HOMA-IR decreased and HOMA-B increased significantly (P<0.01), and TG, CHOL, LDL decreased significantly (P<0.01) after the treatment.

CONCLUSIONShort-term intensive treatment with glimepiride combined with metformin is safe and effective in newly diagnosed type 2 diabetic patients with HbA1c>9%.