Chinese Journal of Oncology 2012;34(11):838-841

doi:10.3760/cma.j.issn.0253-3766.2012.11.009

Expression and significance of Rab5a and APPL1 in breast cancer.

Qian CHEN 1 ; Wei-yan LIU ; Zhen ZHAO ; Yun XIE ; Bao-san HAN

Affiliations

+expand

Country

China

Language

Chinese

MeSH

Abstract

OBJECTIVETo investigate the expression of Rab5a and APPL1 in breast cancer and fibroma, and analyze their correlation with HER-2 expression, metastasis and development of breast cancer.

METHODSRab5a and APPL1 in paraffin embedded tissues of 74 breast carcinomas and 40 breast fibromas were detected by immunohistochemistry. Their relationship with metastasis, pathological grade, and HER-2 expression in breast cancer was determined by statistical analysis.

RESULTSThere was no expression or low expression of Rab5a and APPL1 in the breast fibroma, but the positive expression rate of Rab5a and APPL1 in the breast carcinomas were 91.9% and 83.8%, respectively. No significant difference in expression of Rab5a and APPL1 was found between metastatic and non-metastatic groups, and pathological grade I/II and grade III groups. But Rab5a was overexpressed in HER-2-positive group compared with that in the HER-2-negative group.

CONCLUSIONSRab5a and APPL1 are overexpressed in breast cancer, and are positively correlated with the HER-2 expression. These proteins may influence the growth and proliferation of breast cancer cells by HER-2 signal transduction.