Acta Pharmaceutica Sinica 2014;49(11):1578-1581

Two new sesquiterpenoids from basidiomycete Tyromyces chioneus.

Hua GUO ; Tao FENG ; Zheng-Hui LI ; Ji-Kai LIU

Country

China

Language

English

Abstract

Two new sesquiterpenoids, named as tyromols A and B (1 and 2), were isolated from cultures of basidiomycete Tyromyces chioneus, along with two previously reported 15-hydroxy-6 α, 12-epoxy-7β, 10αH, 11βH-spiroax-4-ene (3) and agripilol C (4). Compounds 1-4 were separated and purified by silica gel, RP-18, Sephadex LH-20 column chromatography. Their structures were elucidated on the basis of extensive spectroscopic analysis including IR, MS, 1D and 2D NMR experiments.