Chinese Journal of Stomatology 2007;42(2):78-79

Expression of drug resistance and metastasis related gene in adenoid cystic carcinoma and mucoepidermoid carcinoma.

Xiao-feng WANG 1 ; Yang GUO ; Shen-shan JIA

Affiliations

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Country

China

Language

Chinese

Abstract

OBJECTIVETo examine the differential gene expression among adenoid cystic carcinoma ACC-M, low metastasis ACC-2 and low differentiated mucoepidermoid carcinoma MEC-1 with gene array, and detect three important genes with real-time quantitative PCR.

METHODSGene array was used to screen the differential genes, then three important genes were selected and detected by real-time quantitative PCR.

RESULTSThe gene contents of MDR-1, MRP-1 and CCD1 were MEC-1 > ACC-M > ACC-2, MEC-1 > ACC-M > ACC-2 and MEC-1 > ACC-M > ACC-2 respectively.

CONCLUSIONSDrug resistance of MEC-1 is related with high content of MDR-1. High metastasis of ACC-M is concerned with high content of MRP-1 and low content of CCD-1. Low metastasis of ACC-2 has a relationship with low content of MRP1.