National Journal of Andrology 2009;15(5):437-440

Diagnostic value of lesion-directed prostate biopsy under TRUS in early detection of prostate cancer.

Jiang ZHU 1 2 ; Xue-Ming LIU ; Chuan-Jun DU ; Zhe-Wei ZHANG ; Yi-Qing QIU ; Yu GONG ; Jing-Rui LIU ; Yu-Rong HONG ; Zhi-Yan LUO ; Yong ZHANG

Affiliations

+expand

Country

China

Language

Chinese

Abstract

OBJECTIVETo evaluate lesion-directed biopsy in improving the detection rate of early prostate cancer (PCa) and in differentiating PCa from other prostate pathological changes.

METHODSWe performed TRUS-guided prostate biopsy for 95 patients suspected of PCa, each subjected to extended random biopsy plus lesion-directed biopsy, and analyzed the sonographic characteristics and pathological findings.

RESULTSPCa was detected in 35 of the patients (36.8%), including 16 hypoechoic (45.7%), 4 hyperechoic (11.4%), 10 isoechoic (28.6%) and 5 mixed hetero-echoic lesions (14.3%). Of the 35 PCa cases, 17 (46.2%) were within T2b, 70.6% (12/17) of which were detected by lesion-directed biopsy and 29.4% (5/17) by sextant biopsy, the former obviously higher than the latter (P < 0.05).

CONCLUSIONLesion-directed prostate biopsy under TRUS can significantly improve the early diagnosis of prostate cancer, increase convenience and reduce patients' pain, but is not sufficient to replace traditional sextant biopsy.