Chinese Journal of Preventive Medicine 2004;38(3):190-192

Effect of static magnetic field on development toxicity of rat embryonic midbrain neurons cells.

Li-rong DUAN 1 ; Quan-yi WU ; Fang-ping LIU

Affiliations

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Country

China

Language

Chinese

MeSH

Abstract

OBJECTIVETo explore the effect of static magnetic field (SMF) on the differentiation and proliferation of rat embryonic midbrain neurons cells.

METHODSThe micromass culture of rat embryonic midbrain neurons cell was applied to study the effect of varieties of SMF (1.0, 10.0, 50.0, 100.0, 200.0 mT) and FACS.

RESULTSSMF inhibited the differentiation of the cell without affecting cell proliferation. The concentration of 50% inhibition of cell differentiation (ICD(50)) was 25 mT. The concentration of 50% inhibition of cell differentiation (IVD(50)) was 45 mT.

CONCLUSIONSThe inhibition of SMF on embryonic midbrain neurons cells may be associated with impact of protein syntheses, and lipid peroxidation.