Acta Academiae Medicinae Sinicae 2016;38(3):360-363

doi:10.3881/j.issn.1000-503X.2016.03.022

Research Advances in CKLFSF-like MARVEL Transmembrane Domain Containing Member 3.

Feng-zhan HU 1 ; Zheng-zuo SHENG 1 ; Cai-peng QIN 1 ; Tao XU 1

Affiliations

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Country

China

Language

English

Abstract

CKLF-like MARVEL transmembrane domain containing member/chemokine-like factor super family member (CKLFSF/CMTM) is a novel tumor suppressor gene. CMTM3 is broadly expressed in normal human tissues and evolutionary conserved,especially in testis,spleen,and some cells of peripheral blood mononuclear cells. However,its expression is undetectable or down-regulated in most carcinoma cell lines and tissues. Restoration of CMTM3 may inhibit the proliferation,migration,and invasion of carcinoma cells. Although the exact mechanism of its anti-tumor activity remains unclear,CKLFSF3/CMTM3 is closely connected with immune system and associated with sex during tumorigenesis. The study advances of CKLFSF3/CMTM3 are elaborated in this review as CMTM3 may be a new target in the gene therapies for tumors,especially genitourinary tumors,while further studies on CMTM3 and its anti-tumor mechanisms are warranted.