Journal of Zhejiang University. Medical sciences 2002;31(1):26-29

Experimental study on allogeneic mandible transplantation combined with basic fibroblast growth factor

Hui-Yong ZHU 1 ; Qiu-Liang WU ; Ming ZHANG ; Ji-An HU ; Zhi-Qiang CHAO ; Song-Ying LI

Affiliations

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Country

China

Language

Chinese

Abstract

OBJECTIVE: To study the effect of basic fibroblast growth factor(b-FGF) on revascularization and bone remodeling of allogeneic mandible transplantation in repair of mandible defects in rabbits. METHODS: The mandible defects of 20 adult rabbits were created in both sides. The defects on the left side were implanted with allogeneic bone and local administration of b-FGF; the defects on the right side were only repaired with allogeneic bone as control group. At 1, 3 months after operation, the revascularization and bone remodeling were observed by ink-gelation vascular perfusion-transparency and histological examination. RESULTS: The allogeneic bone and b-FGF group had more marked vascularization and more quick and complete bone formation than control group. CONCLUSION: b-FGF can improve revascularization and bone formation after allogeneic mandible transplantation; allogeneic bone combined with b-FGF is a promising bone substitute in clinical uses.