Chinese Journal of Medical Genetics 2007;24(1):101-103

Study on the association between the HLA-DRB1 alleles and type 2 diabetes in Yi nationality of Yunnan.

Hong-ying YANG 1 ; Li XUE ; Mian XU ; Chun-feng REN ; Hui-yun YUAN ; Wen-lin TAI ; Yu YANG ; Wei HE

Affiliations

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Country

China

Language

Chinese

Abstract

OBJECTIVETo investigate the association between the polymorphism of HLA-DRB1 alleles and type 2 diabetes mellitus in Yi nationality of Yunnan.

METHODSPolymerase chain reaction-sequence specific primers (PCR-SSP) genotyping method was conducted in 79 patients with type 2 diabetes mellitus and 47 ethnically matched controls in Yi Nationality Autonomous Prefecture, Chuxiong.

RESULTSHLA-DR7 and DR11 allele frequencies in type 2 diabetic mellitus patients were significantly higher than those in non-diabetic control subjects respectively(P is 0.009, RR is 8.329;P is 0.029, RR is 7.734).

CONCLUSIONDR7 and DR11 alleles are probably susceptible genes of type 2 diabetes mellitus in Yunnan Yi nationality.