Acta Academiae Medicinae Sinicae 2002;24(3):298-301

Serum levels of macrophage colony stimulating factor in the patients with Alzheimer's disease.

Qing-li KONG 1 ; Jian-min ZHANG ; Zhen-xin ZHANG ; Ping-jiang GE ; Ya-jun XU ; Ru-shun MI ; Yu-hua ZHAO ; Yan-ping SUI ; Wei HE

Affiliations

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Country

China

Language

Chinese

Abstract

OBJECTIVETo investigate the availability of serum level of macrophage clony stimulating factor (M-CSF) as a marker for early diagnosis of Alzheimer's disease (AD).

METHODSThe serum levels of M-CSF in 70 patients with AD, 52 healthy controls, 22 patients with VAD (vascular dementia) were measured and the serum levels of IL-1 beta, IL-6, TNF-alpha in 32 patients with AD and 20 controls were measured as well.

RESULTSSerum levels of M-CSF were significantly elevated in patients with AD when compared with healthy controls (P < 0.01) and VAD controls (P < 0.05) respectively. At the early stage of mild dementia and middle dementia, serum levels of M-CSF were significantly elevated, but at the later stage of severe dementia, they returned to normal level. Serum levels of IL-1 beta were significantly elevated in AD patients compared with controls (P < 0.05), and serum levels of TNF-alpha and IL-6 were within the normal range in patients with AD.

CONCLUSIONSThe results suggest that serum M-CSF level may provide a convenient and sensitive means for the early diagnosis of Alzheimer's disease.