Biomedical and Environmental Sciences 2014;27(11):841-848

doi:10.3967/bes2014.110

Detection of human bocavirus in children with acute respiratory tract infections in Lanzhou and Nanjing, China.

Jian Jun WU 1 ; Yu JIN 2 ; Na LIN 3 ; Zhi Ping XIE 3 ; Jie Mei YU 3 ; Jin Song LI 3 ; Chang Qing CAO 2 ; Xin Hui YUAN 2 ; Jin Rong SONG 2 ; Jing ZHANG 2 ; Yang ZHAO 2 ; Xiao Qian GAO 2 ; Zhao Jun DUAN 3

Affiliations

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Keywords

Child; Human bocavirus; Respiratory tract infections

Country

China

Language

English

MeSH

Abstract

OBJECTIVEThe aim of this study was to explore the prevalent characteristics of HBoV1 and its co-infection.

METHODSPCR was used to detect HBoV1-DNA (HBoV1) and other viruses. A multivariate logistic regression model was used to explore possibility of co-detected for related viruses.

RESULTSThe positivity rates in Nanjing and Lanzhou were 9.38% (74/789) and 11.62% (161/1386), respectively (P>0.05). The HBoV1 positive group was younger than negative group (P<0.05). Seasonal differences were noted, with a higher frequency of infection in December and July. HBoV1-positive children [72.34% (169/235)] were co-infected with other respiratory viruses. Multifactorial analysis showed no correlations between HBoV1 and the clinical classification, region, gender, age, or treatment as an outpatient or in a hospital. Correlations were identified between HBoV1 infections with ADV (OR=1.53, 95% CI 1.03-2.28), RSV (OR=0.71, 95% CI 0.52-0.98), and IFVA (OR=1.77, 95% CI 1.00-3.13).

CONCLUSIONPresence of HBoV1 in nasopharyngeal aspirates did not correlate with region or gender, although the prevalence of HBoV1 was higher in younger children. There were no correlations between HBoV1 and other variables, except for the season and ADV, RSV, or IFVA infections.