Chinese Journal of Applied Physiology 2002;18(1):5-8

Research of regulation on calcium-activated potassium channel in hypothalamic neurons by nitric oxide.

Shuai WANG 1 ; Zhen-Gang WANG ; Xu-Dong ZHANG ; Fei ZOU

Affiliations

+expand

Country

China

Language

Chinese

Abstract

AIMTo study the effects of nitric oxide on calcium-activated potassium channels (KCa) in hypothalamus neurons.

METHODSThe data was recorded by adopting cell-attached or inside-out configuration of patch-clamp technique.

RESULTSNitric oxide was found to increase the open probability of the channels directly or through increasing cGMP, which resulted from both the prolongation of open period and increase of open frequency.

CONCLUSIONNitric oxide could regulate calcium-activated potassium channels in hypothalamic neurons through alternative pathways.