Chinese Journal of Integrated Traditional and Western Medicine 2006;26 Suppl():39-43

Study on the pharmacological mechanism of analgesic effect of injection stauntoniae.

Su CHEN 1 ; Xiang-ming LIU ; Fan ZHANG

Affiliations

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Country

China

Language

Chinese

Abstract

OBJECTIVETo study the effects of Injection Stauntoniae (IS) on voltage-gated sodium currents in dorsal root ganglion neurons and analyze its pharmacological mechanism of blocking the nerve conduction and anal gesic action.

METHODSWhole-cell patch-clamp recordings were performed in acutely isolated rat dorsal root ganglion neurons and the effects of 10% , 25% and 50 % IS on voltage-gated sodium currents were observed.

RESULTSIS inhibited the peak sodium currents in dorsal root ganglion neurons in a dose-dependent way and affected the activation and inactivation process of the channels.

CONCLUSIONThe analgesic effect of IS was presumably caused by modulation of voltage-gated sodium channels in primary sensory neurons besides structure destruction of myelin sheath and axon membrane.