Chinese Journal of Integrated Traditional and Western Medicine 2006;26 Suppl():58-60

Changes of serum nitric oxide level after acute hepatic injury in mice and the effect of yugan capsule on it.

Xin CHENG 1 ; Chao-liang XIE ; Jing WANG

Affiliations

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Country

China

Language

Chinese

Abstract

OBJECTIVETo observe the changes of serum nitric oxide (NO) level after acute hepatic injury (AHI) in mice and the effect of Yugan capsule (YC) on it.

METHODSThe mouse AHI model was induced by carbon tetrachloride ( CC14 ) at different time points. After treatment with or without YC, serum nitric oxide ( NO) , anlanine aminotransferase (ALT) and aspartate aminotransferase (AST) were detected, and liver histopathologic injury was observed at different time points after AHI, respectively.

RESULTSSerum NO, ALT and AST in the model group escalated significantly with time going, while they decreased and liver histopathologic injury was improved in the YC groups.

CONCLUSIONThe serum levels of NO, ALT and AST increased,and liver histopathologic injury gradually aggravated with time going after CCl4 injection. Yugan capsule could decrease the levels of ALT, AST and NO.