Chinese Journal of Oncology 2004;26(12):732-734

Influence of chemotherapy on Th1/Th2 cytokine switching in stomach cancer patients.

Yan LI 1 ; Jing LIANG ; Wen-bo LIU ; Xiao-qun XU ; Yue-ran ZHAO

Affiliations

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Country

China

Language

Chinese

MeSH

Abstract

OBJECTIVETo observe the influence of chemotherapy on the switching of Th1/Th2 cytokines in stomach cancer patients.

METHODSTh1/Th2 cytokine genes expressed by peripheral blood mononuclear cells of stomach cancer patients before and after chemotherapy were detected by RT-PCR.

RESULTSThe expression of Th2 cytokines was dominant in patients before chemotherapy, and the dominancy became less marked after chemotherapy.

CONCLUSIONThe immune deviation with Th2 predominance in stomach cancer patients has a tendency to become reversed after chemotherapy.