Chinese Journal of Experimental and Clinical Virology 2008;22(1):60-62

Acute transverse myelitis associated with coxsackievirus B---A retrospective analysis of 7 patients.

Zhan-dong LIU 1 ; De-xin WANG ; Zi-jing FENG

Affiliations

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Country

China

Language

Chinese

MeSH

Abstract

OBJECTIVEAcute Transverse myelitis (ATM) is a focal inflammatory disorder of the spinal cord, resulting in motor, sensory, and autonomic nerve dysfunction. There is often a clearly defined rostral border of sensory dysfunction. Nowadays, the pathogenesis of ATM is not clear. The present study aimed to understand possible relationship between ATM and infection with Coxsackievirus B.

METHODSIgM antibody against Coxsackievirus B was detected in cerebrospinal fluid of 33 patients with ATM.

RESULTSIn 7 of the 33 cases with ATM, the IgM andtibody Coxsackievirus B (CVB) was positive. No infections with other pathogens were found at the onset of the disease.

CONCLUSIONThe pathogenesis of ATM may involve infection with Coxsackievirus B.