Chinese Journal of Gastrointestinal Surgery 2015;18(4):305-308

Application of gene mutation detection in gastrointestinal stromal tumors.

Yachao HOU 1 ; Jingyu DENG ; Han LIANG

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Country

China

Language

Chinese

Abstract

Gastrointestinal stromal tumors(GISTs) are the most common gastrointestinal mesenchymal tumors of the gastrointestinal tract. Most of GISTs are characterized by mutation in the c-kit or PDGFR-α genes. In recent years, detection of gene mutation in GISTs has been widely used. In addition to the contribution to the diagnosis of difficult cases, such detection also has important value in predicting the efficacy of therapeutic drugs targeting, guiding clinical treatment and evaluating the prognosis of patients. In a word, gene mutation detection should be considered as the important standard for exact diagnosis and treatment of GISTs.