Chinese Journal of Medical Genetics 2011;28(1):64-68

doi:10.3760/cma.j.issn.1003-9406.2011.01.015

Negative association of STAMP2 gene polymorphisms with essential hypertension in Xinjiang Uygur population.

Yun-wei BI 1 ; Chang-min WANG ; Zhi-tao YAN ; Nan-fang LI ; Yan-ying GUO ; Hong-mei WANG ; Xiao-guang YAO ; Deng-pan LIANG

Affiliations

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Country

China

Language

Chinese

Abstract

OBJECTIVETo investigate the relationship between the genetic polymorphisms of the six transmembrane protein of prostate 2 gene (STAMP2) and essential hypertension in Xinjiang Uygur population.

METHODSThe sequences of STAMP2 gene functional region were sequenced in Xinjiang Uygur population with hypertension. The representative variations selected were genotyped by TaqMan-PCR method in 2047 Uygur individuals, including 810 patients with hypertension and 1237 healthy subjects. The association of the genetic variations of the STAMP2 gene with hypertension in Uygur was analyzed.

RESULTSIn the three representative variations (rs8122, rs1981529 and rs34741656) genotyped, there were no significant differences in genotype distribution and allele frequencies between the essential hypertension and control groups (P > 0.05). In ANCOVA analysis, none of the polymorphisms was significantly associated with systolic blood pressure and diastolic blood pressure (P > 0.05). There were no significant differences in haplotype frequencies between the two groups either(P > 0.05).

CONCLUSIONThere was no association of the three polymorphisms (rs8122, rs1981529 and rs34741656) in the STAMP2 gene with essential hypertension in Xinjiang Uygur population.