Chinese Journal of Medical Genetics 2011;28(1):69-72

doi:10.3760/cma.j.issn.1003-9406.2011.01.016

No association of K469E polymorphism of intercellular adhesion molecule-1 with rheumatoid arthritis.

Zhao-lin YUAN 1 ; Xiao-xue ZHANG ; Bo SHEN ; Min ZHU ; Wei XU ; Jun LI ; Jian-xin LV

Affiliations

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Country

China

Language

Chinese

Abstract

OBJECTIVETo investigate the association of the intercellular adhesion molecule-1 gene (ICAM-1) K469E polymorphism and rheumatoid arthritis (RA).

METHODSTwo hundred and seventy-five patients with RA and 254 healthy individuals were collected and enrolled in the study. The K469E polymorphism of ICAM-1 gene was analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).

RESULTSThe genotype frequencies of KK, KE and EE of K469E polymorphism were 0.535,0.411 and 0.054 respectively in the RA patients, and 0.512,0.437 and 0.051 respectively in the healthy individuals, and there was no significant difference between the two groups (chi² = 0.371, P = 0.831). The frequencies of the K469 allele were 0.74 and 0.73 in the RA patients and the controls respectively (chi² = 0.127, P = 0.721, OR = 1.051, 95%CI:0.800-1.381). No significant difference was observed in KK + KE genotype frequencies between the two groups (P = 0.863), with an odds ratio of 0.935 (95%CI:0.436-2.005).

CONCLUSIONThe K469E polymorphism of the ICAM-1 gene was not associated with the susceptibility of rheumatoid arthritis.