Journal of Experimental Hematology 2006;14(4):849-852

Dendritic cells and transplantation immune tolerance--review.

Hui ZENG 1 ; Guang-Sheng HE ; De-Pei WU

Affiliations

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Country

China

Language

Chinese

Abstract

Dendritic cells (DC) play an important roles in the maintenance of central immune tolerance and peripheral immune tolerance. DC can be involved in formation of autoimmune tolerance by many mechanisms and demonstrate strong plasticity, so that DC become hot issue in the research of transplantation tolerance recently. In this article the DC typing and its role, the indirect pathway of DC-inducing immune tolerance, the F1t3L and apoptotic cell role, the modified DC by genetic engineering and the immune inhibitors were summarized.