Biomedical and Environmental Sciences 2006;19(5):367-370

In vitro potentiation of antimalarial activities by daphnetin derivatives against Plasmodium falciparum.

Fang HUANG 1 ; Lin-Hua TANG ; Lin-Qian YU ; Yi-Chang NI ; Qin-Mei WANG ; Fa-Jun NAN

Affiliations

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Country

China

Language

English

Abstract

OBJECTIVETo screen the antimalarial compounds of daphnetin derivatives against Plasmodium falciparum in vitro.

METHODPlasmodium faciparum (FCC1) was cultured in vitro by a modified method of Trager and Jensen. Antimalarial compounds were screened by microscopy-based assay and microfluorimetric method.

RESULTSDA79 and DA78 showed potent antimalarial activity against Plasmodium falciparum cultured in vitro.

CONCLUSIONThough the relationship between the structures of daphnetin derivatives and their antimalarial activities has not been clarified yet, this study may provide a new direction for discovery of more potential antimalarial compounds.