Chinese journal of integrative medicine 2016;22(12):889-893

Efficacy and safety of Qiaoshao Formula () on patients with lifelong premature ejaculation of Gan (Liver) depression and Shen (Kidney) deficiency syndrome: A randomized controlled trial.

Jun GUO 1 ; Qing-He GAO 1 ; Fu WANG 2 3 ; Guo-Jin YU 1 ; Ji-Wei ZHANG 1 ; Yin ZENG 1 ; Qiang GENG 4 ; Bo-da GUO 5 ; Qiang HAN 6

Affiliations

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Keywords

Chinese medicine; Qiaoshao Formula; dapoxetine; intra-vaginal ejaculation latency time; lifelong premature ejaculation; premature ejaculation diagnostic tool

Country

China

Language

English

Abstract

OBJECTIVETo observe the effificacy and safety of Qiaoshao Formula (, QSF) on patients with lifelong premature ejaculation (LPE) of Gan (Liver) depression and Shen (Kidney) defificiency syndrome.

METHODSA total of 60 LPE patients were randomly divided into treatment (QSF) and control (dapoxetine) groups. The treatment group received QSF twice a day and the control group received dapoxetine 1 to 2 h prior to planned sexual intercourse for 4 weeks. The outcomes included intra-vaginal ejaculation latency time (IELT), premature ejaculation diagnostic tool (PEDT), clinical global impression of change (CGIC), scores of Chinese medicine symptoms (CMSS), sex life satisfaction (SLS) and adverse events (AEs).

RESULTSIn the treated group, the median IELT was 3 min vs. 1.5 min before and after treatment (P<0.05). PEDT in the treated group was reduced to 11.76±1.68 from 15.83±2.30 after treatment (P<0.05). Besides, patient's SLS was improved from 1.30±0.05 to 6.30±0.04 (P<0.05), and spouse's SLS was increased from 1.30±0.to 6.10±0.06 (P<0.05); CMSS was decrease from 14.86±3.02 to 9.62±2.87 (P<0.05). In addition, no significant AE was observed in both groups.

CONCLUSIONQSF may be effective and safe on LPE patients with Gan depression and Shen defificiency syndrome.