Cancer Research and Treatment  2004;36(5):275-286

Transcription Factors in the Cellular Signaling Network as Prime Targets of Chemopreventive Phytochemicals.

Young Joon SURH 1

Affiliations

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Keywords

Chemoprevention; Phytochemicals; Signal transduction; Cell signaling network; NF- kappa B; AP-1; Mitogen-activated protein kinases; Nrf2; Keap1

Country

Republic of Korea

Language

English

Abstract

Accumulating evidence from epidemiologic and laboratory studies support an inverse relationship between a regular consumption of fruits and vegetables and the risk of specific cancers. Numerous phytochemicals derived from edible plants have been reported to possess ability to interfere with a specific stage of carcinogenic process. Multiple mechanisms have been proposed to account for the anti-carcinogenic actions of dietary constituents, but more attention has recently focussed on intracellular signaling cascades as common molecular targets of a wide variety of chemopreventive phytochemicals.