Anatomy & Cell Biology  2016;49(4):223-230

doi:10.5115/acb.2016.49.4.223

Galanin's implications for post-stroke improvement.

Juhyun SONG 1 ; Oh Yoen KIM

Affiliations

+expand

Keywords

Galanin; Post-stroke; Depression; Inflammation; Cognitive decline

Country

Republic of Korea

Language

English

Abstract

Stroke leads to a variety of pathophysiological conditions such as ischemic infarct, cerebral inflammation, neuronal damage, cognitive decline, and depression. Many endeavors have been tried to find the therapeutic solutions to attenuate severe neuropathogenesis after stroke. Several studies have reported that a decrease in the neuropeptide regulator ‘galanin’ is associated with neuronal loss, learning and memory dysfunctions, and depression following a stroke. The present review summarized recent evidences on the function and the therapeutic potential of galanin in post-ischemic stroke to provide a further understanding of galanin's role. Hence, we suggest that galanin needs to be considered as a therapeutic factor in the alleviation of post-stroke pathologies.