Journal of Clinical Neurology  2006;2(4):286-289

doi:10.3988/jcn.2006.2.4.286

Recurrent Cerebral Venous Thrombosis Associated with Elevated Factor VIII.

Mi Jung KIM 1 ; A Hyun CHO ; Young Joo NO ; Hee Young KIM ; Jong S. KIM

Affiliations

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Keywords

Cerebral venous sinus thrombosis; Coagulation factor VIII

Country

Republic of Korea

Language

English

Abstract

Cerebral venous thrombosis (CVT) rarely recurs, and the factors associated with a recurrence remain unclear. Recently, however, elevated plasma coagulation factor VIII has been considered a factor related to recurrent venous thromboembolism. Here we report a patient who had recurrent CVT associated with significantly elevated levels of factor VIII despite the chronic use of an antiplatelet agent. Factor IX was also elevated in this patient. These findings suggest that elevated factor VIII is a factor underlying the recurrence of CVT, and that prolonged anticoagulation therapy may have to be considered in patients with elevated coagulation factor levels.