OBJECTIVE: Although currently only a few middle cerebral artery aneurysms (MCAAs) are inoperable, they still present problems as compared with other aneurysm in the anterior circulaton. MCAAs are less suitable for endovascular surgery, owing to anatomic reasons and frequent association with expanding hematomas, neurosurgeons should focus on the safe treatment of these lesions. Several methods are recently available for the clipping of wide-necked MCAAs. The author emphasizes the techique of multiple clipping in the present study. METHODS: This article contains 5 patients with wide-necked MCAAs who underwent multiple clipping technique with facing and/or tandem fashion, in which the tips of the clip blades are placed in opposite or parallel directions, respectively. RESULTS: Aneurysms were successfully clipped with preservation of the parent vessels. There were four good results and one death directly related to the initial brain injury. CONCLUSION: On the basis of the configurations of domes and their neck, wide-necked MCAAs can be clipped successfully using this multiple clipping technique with facing and tandem fashion.