Journal of the Korean Society of Neonatology  2010;17(1):109-115

Two Cases of Neonatal Persistent Pulmonary Hypertension Treated by Veno-venous Extracorporeal Membrane Oxygenation (V-V ECMO).

Hee Joon YU 1 ; Se In SUNG ; Jin Kyu KIM ; Hyun Joo SEO ; Seo Heui CHOI ; Hye Soo YOO ; So Yoon AHN ; Eun Sun KIM ; Ji Hyuk YANG ; June HUH ; Yun Sil CHANG ; I Seok KANG ; Tae Kook JUN ; Won Soon PARK

Affiliations

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Keywords

Persistent pulmonary hypertension of the newborn; Meconium aspiration syndrome; Respiratory failure; Veno-veno extracorporeal membrane oxygenation

Country

Republic of Korea

Language

Korean

Abstract

Persistent pulmonary hypertension in newborns (PPHN) is a disorder of the vascular transition from fetal to neonatal circulation. It results in cyanosis due to right-to-left shunting of the blood through the ductus arteriosus and/or foramen ovale manifesting as hypoxemic respiratory failure. We managed two cases of PPHN after meconium aspiration with high frequency oscillating ventilators and inhaled nitric oxide. They did not respond to conventional management. Veno-venous extracorporeal membrane oxygenation (ECMO) was provided, and ECMO weaning was possible resulting survivals in two cases. We report two PPHN cases, which were treated successfully with veno-venous ECMO for the first time in Korea.