Journal of the Korean Society for Therapeutic Radiology  1987;5(1):13-22

The Effect of Hyperthermia Combined with Radiation on Crypts of the Mouse Jejunum.

Hoon Sik BAE 1 ; Charn Il PARK ; Jung Jin KIM

Affiliations

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Keywords

Hyperthermia; Radiation; Jejunal crypt microcolony

Country

Republic of Korea

Language

English

Abstract

The effect of local hyperthermia of 41 to 43degree C for 30 minutes on radiosensitivity of normal tissue was studied utilizing jejunal crypt microcolony assay. Hyperthermia of this range enhanced the radiation effect and the effect was mainly additive without significant effect on the slopes of cell survival curves. At the isoeffect level of 20 microcolony formation, the thermal enhancement ratio was 1.02, 1.10 and 1.39 for 41degree 42degreeand 43degree C, respectively. The distribution of microcolony formation along the circumference of jejunum was not uniform, having more colonies around the mesenteric border, and this suggests the effect of uneven cooling by blood circulation.