The Journal of the Korean Rheumatism Association  2002;9(2):137-140

Deep Neck Infection due to Severe Neutropenia induced by Terbinafine in a Patient with Systemic Lupus Erythematosus.

Jong Tae YANG 1 ; Young Shin CHO ; Yoo Chul JOO ; Dai Yong JANG ; Jong O KIM ; Hee Kwan KOH

Affiliations

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Keywords

Terbinafine; Neutropenia; Systemic Lupus Erythematosus

Country

Republic of Korea

Language

Korean

Abstract

Terbinafine, a fungicidal agent used for the treatment of onychomycosis, has been found to be safe and adverse effects are usually mild and transient. Neutropenia is a rare side effect of terbinafine. Terbinafine-induced neutropenia have been reported 7 cases worldwide and these patients had no predisposing factors that give rise to developing neutropenia. To date there has not been reported in Korea. We report a case of systemic lupus erythematosus of 47-yearold female patient who developed deep neck infection requiring intravenous antibiotics, tracheostomy, granulocyte colony-stimulating factor(G-CSF) to recover from terbinafine-induced neutropenia.