The Korean Journal of Internal Medicine  2002;17(1):73-77

A Case of Neurotoxicity Following 5-Fluorouracil-based Chemotherapy.

Seung Seog KI 1 ; Jin Mo JEONG ; Seong Ho KIM ; Sook Hyang JEONG ; Jin Hyuk LEE ; Chul Ju HAN ; You Cheol KIM ; Jhin Oh LEE ; Young Joon HONG

Affiliations

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Keywords

Fluorouracil; Neuorotoxicity syndromes; Leukoencephalopathy, progressive multifocal

Country

Republic of Korea

Language

English

Abstract

5-Fluorouracil (5-FU) is a commonly used chemotherapeutic agent. However, its neurotoxicity is rare and not well recognized. We report a case of 5-FU neurotoxicity with organic brain syndrome and progression to multifocal leukoencephalopathy in a 44-year-old male patient having malignant gast- rointestinal stromal tumor. 5-FU-induced neurotoxicity should, therefore, be considered as an important differential diagnosis in cancer patients with neurological abnormality and history of chemotherapy.