Korean Journal of Pediatrics  2013;56(5):227-230

doi:10.3345/kjp.2013.56.5.227

Two cases of chronic pancreatitis associated with anomalous pancreaticobiliary ductal union and SPINK1 mutation.

Eun Sam RHO 1 ; Earl KIM ; Hong KOH ; Han Wook YOO ; Beom Hee LEE ; Gu Hwan KIM

Affiliations

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Keywords

Chronic pancreatitis; Anomalous pancreaticobiliary ductal union; Serine protease inhibitor; Kazal type 1

Country

Republic of Korea

Language

English

Abstract

Chronic pancreatitis is a progressive inflammatory disease resulting from repeated episodes of acute pancreatitis that impair exocrine function and eventually produce endocrine insufficiency. Some causes of chronic pancreatitis appear to be associated with alterations in the serine-protease inhibitor, Kazal type 1 (SPINK1), cationic trypsinogen (PRSS1), and cystic fibrosis-transmembrane conductance regulator (CFTR) genes, or with structural disorders in the pancreaticobiliary ductal system, such as pancreatic divisum or anomalous pancreaticobiliary ductal union (APBDU). However, it is unusual to observe both genetic alteration and structural anomaly. Here, we report 2 cases with both APBDU and a mutation in the SPINK1 genes, and we discuss the implications of these findings in clinical practice.