Journal of the Korean Society of Emergency Medicine  2001;12(4):536-540

A Case of Primary Central Nervous System Lymphoma with Panhypopituitarism.

Won Young KIM 1 ; Won KIM ; Gyu Chong CHO ; Jung Suck HONG ; Mi Woo LEE ; Sung Eun JANG ; Se Hyun OH ; Kyoung Soo LIM

Affiliations

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Keywords

Primary central nervous system lymphoma; Panhypopituitarism

Country

Republic of Korea

Language

Korean

Abstract

A primary central nervous system lymphoma(PCNSL) is defined as a lymphoma limited to the cranialspinal axis without systemic involvement. PCNSLs were formerly very rare, only 0.5~1.2% of all intracranial neoplasms, and were usually associated with acquired immuno-deficiency syndrome(AIDS) and other immuno-compromised states. Recently, there has been a clear rise in the incidence of this disease among normal individuals. We describe a 77-year-old female with hyponatremia who presented with a confused mental state. Computed tomography(CT) of the brain demonstrated a suprasellar mass with enhancement. We evaluated the basic hormonal studies and the magnetic resonance imaging(MRI). A ventricular biopsy was done, and the result was a diffuse, large, B-cell-type malignant lymphoma. She presented panhypopituitarism and partial central diabetes insipidus. She received chemotheraphy and was discharged in an improved condition. We report a case of panhypopituitarism due to PCNSL and give a review of the literature.