Natural Product Sciences  2016;22(2):82-86

doi:10.20307/nps.2016.22.2.82

Compounds from a jellyfish-derived fungus Aspergillus fumigates.

Guan Yu TAO 1 ; Juan LIU ; Jee H JUNG ; Wei GUO ; Xiao Qiong WEN ; Yonghong LIU

Affiliations

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Keywords

Nemopilema nomurai; Jellyfish-derived fungus; Aspergillus fumigates; Isolation; Structural elucidation

Country

Republic of Korea

Language

English

Abstract

Six compounds were isolated from the secondary metabolites of the jellyfish-derived fungus Aspergillus fumigates, whose structures were identified by chemical methods and spectroscopic analysis as pseurotin F1 (1), azaspirofurans B (2), (22E, 24R)-24-methyl-5α-cholesta-7,22-diene-3β,5,6β-triol (3), 5α,8α-epidioxyergosta-6,22-dien-3β-o1 (4), cyclo-(L-Pro-L-Tyr) (5), fumitremorgin C (6). The compounds 1 - 5 were isolated from the fungus Aspergillus fumigates for the first time. The isolated compounds (1 - 6) were evaluated for antibiotic activity and cytotoxicity against six bacterial strains and ten human tumor cell lines, respectively.