Korean Journal of Anesthesiology  1993;26(2):310-313

doi:10.4097/kjae.1993.26.2.310

Blood Concentration of Lidocaine after Subarachnoid Administration.

Jae Kyu CHEUN 1 ; Ae Ra KIM ; Dae Lim JEE ; Yeon Kyu KIM

Affiliations

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Keywords

Spinal anesthesia; Blood lidocaine concentration

Country

Republic of Korea

Language

Korean

Abstract

Ten healthy adult female patients scheduled for elective abdominal hysterectomy were evaluated for their rates and degrees of absorption following subarachnoid administration of 150 mg of 5% lidocaine in 5% dextrose solution. The mean blood concentrations of lidocaine measured at 5, 15, 30, 60 and 90 minutes after subarachnoid administration were 0.34+/-0.23, 0.78+/-0.27, 1.10+/-0.26, 1.24+/-0.24 and 1.07+/-0.19 mcg/ ml, respectively. The mean values of Cmax and Tmax obtained from these measurements were 1.30+/- 0.21 mcg/ml and 57+/-17 minutes, respectively. These results revealed that in comparison with other regional administration, absorption of lidocaine follwing subarachnoid injection is slower.