Toxicological Research  2012;28(1):51-56

The Safety Evaluation of a Potent Angiogenic Activator, Synthetic Peptide (SFKLRY-NH2) for the Skin Application.

Dong Ha KIM 1 ; Yun Young LIM ; Hyeong Mi KIM ; So Young KIM ; Beom Joon KIM ; Sung Gil PARK ; Taehoon LEE ; Soo Muk CHO

Affiliations

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Keywords

PS-SPCL; Safety; Skin irritation test; SFKLRY-NH2; W3 peptide

Country

Republic of Korea

Language

English

Abstract

A novel synthetic hexapeptide (SFKLRY-NH2) that displays angiogenic activity has been identified by positional scanning of a synthetic peptide combinatorial library (PS-SPCL). This study was carried out to investigate the irritation of the SFKLRY-NH2 on the skin. The tests were performed on the basis of Korea Food and Drug Administration (KFDA) guidelines. In results, cell toxicity is not appeared for SFKLRY-NH2 in HaCaT cells and B16F10 cells. SFKLRY-NH2 induced no skin irritation at low concentration (10 microM), mild irritation at high concentration (10mM). We consider that this result is helpful for saying about the safety of SFKLRY-NH2 in clinical use.